Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p236 | Genetics and Epigenetics | ECTS2016

Interaction between periostin gene (Postn) and other gene polymorphism involved in periostin expression and activity on bone microstructure in humans

Pepe Jessica , Bonnet Nicolas , Herrmann Francois , Biver Emmanuel , Rizzoli Rene , Chevalley Thierry , Livio Ferrari Serge

Background: Periostin is a matricellular protein involved in bone modeling and remodeling through the modulation of WNT-β catenin signaling in osteoblasts and osteocytes.Aim: To investigate the interaction between polymorphisms of six periostin SNPs and other gene polymorphism involved in periostin expression and activity on periostin serum levels and bone microarchitecture in a cohort of postmenopausal women.Methods: A total ...